New developments in clinical aspects of lymphatic disease
Identifieur interne : 002778 ( Main/Exploration ); précédent : 002777; suivant : 002779New developments in clinical aspects of lymphatic disease
Auteurs : Peter S. Mortimer [Royaume-Uni] ; Stanley G. Rockson [États-Unis]Source :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cellulite sous-cutanée (immunologie), Cellulite sous-cutanée (microbiologie), Humains, Lymphadénite (anatomopathologie), Lymphadénite (immunologie), Lymphoedème (), Lymphoedème (diagnostic), Lymphoedème (génétique), Lymphoedème (immunologie), Maladie de Crohn (physiopathologie), Métastase lymphatique, Obésité (physiopathologie), Prédisposition génétique à une maladie, Tumeurs (anatomopathologie), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (physiopathologie).
- MESH :
- anatomopathologie : Lymphadénite, Tumeurs, Vaisseaux lymphatiques.
- diagnostic : Lymphoedème.
- génétique : Lymphoedème.
- immunologie : Cellulite sous-cutanée, Lymphadénite, Lymphoedème.
- microbiologie : Cellulite sous-cutanée.
- physiopathologie : Maladie de Crohn, Obésité, Vaisseaux lymphatiques.
- Animaux, Humains, Lymphoedème, Métastase lymphatique, Prédisposition génétique à une maladie.
English descriptors
- KwdEn :
- Animals, Cellulitis (immunology), Cellulitis (microbiology), Crohn Disease (physiopathology), Genetic Predisposition to Disease, Humans, Lymphadenitis (immunology), Lymphadenitis (pathology), Lymphatic Metastasis, Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Lymphedema (diagnosis), Lymphedema (genetics), Lymphedema (immunology), Lymphedema (therapy), Neoplasms (pathology), Obesity (physiopathology).
- MESH :
- diagnosis : Lymphedema.
- genetics : Lymphedema.
- immunology : Cellulitis, Lymphadenitis, Lymphedema.
- microbiology : Cellulitis.
- pathology : Lymphadenitis, Lymphatic Vessels, Neoplasms.
- physiopathology : Crohn Disease, Lymphatic Vessels, Obesity.
- therapy : Lymphedema.
- Animals, Genetic Predisposition to Disease, Humans, Lymphatic Metastasis.
Abstract
The lymphatic system is fundamentally important to cardiovascular disease, infection and immunity, cancer, and probably obesity — the four major challenges in healthcare in the 21st century. This Review will consider the manner in which new knowledge of lymphatic genes and molecular mechanisms has demonstrated that lymphatic dysfunction should no longer be considered a passive bystander in disease but rather an active player in many pathological processes and, therefore, a genuine target for future therapeutic developments. The specific roles of the lymphatic system in edema, genetic aspects of primary lymphedema, infection (cellulitis/erysipelas), Crohn’s disease, obesity, cancer, and cancer-related lymphedema are highlighted.
Url:
DOI: 10.1172/JCI71608
PubMed: 24590276
PubMed Central: 3938261
Affiliations:
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Le document en format XML
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This Review will consider the manner in which new knowledge of lymphatic genes and molecular mechanisms has demonstrated that lymphatic dysfunction should no longer be considered a passive bystander in disease but rather an active player in many pathological processes and, therefore, a genuine target for future therapeutic developments. The specific roles of the lymphatic system in edema, genetic aspects of primary lymphedema, infection (cellulitis/erysipelas), Crohn’s disease, obesity, cancer, and cancer-related lymphedema are highlighted.</p></div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S." last="Mortimer">Peter S. Mortimer</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Rockson, Stanley G" sort="Rockson, Stanley G" uniqKey="Rockson S" first="Stanley G." last="Rockson">Stanley G. Rockson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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